Endocrine Abstracts

Introduction: Noonan syndrome is a genetic disorder that usually occurs on a sporadic basis (de novo mutuations) or with autosomal dominant inheritance. Patients present with dysmorphic facial features, cardiac disorders and short stature. Delay of puberty can also be noted. We present here an adult case of Noonan syndrome.Presentation: A 25 years old male presented to our department with low stature, decreased libido and absence of any secondary sexual ...

Introduction: Gonadal dysgenesis is a rare cause of primary amenorrhoea, and refers to a number of conditions in which gonadal development is abnormal leading to streak or hypoplastic gonads. We present a rare case of a girl with primary amenorrhea, tall stature, gonadal dysgenesis and karyotype 46,XX. A 15 years old girl with primary amenorrhoea referred to our department for futher investigation. On clinical examination she was tall (height 1.74 m), her weight was 76 kg and ...

Primary Paraganglioma of Thyroid Gland is an extremely rare neuroendocrine tumor. Less than 50 cases have been reported up to date and its rarity is the reason why it’s often mistaken for thyroid nodule or other thyroid neoplasms. In this case we describe the misleading results of ultrasonography followed by FNA-biopsy, which led to a total delay of two years until final diagnosis. A 60 year old female presented with a 38 mm right-sided thyroid module. An ultrasound guide...

Aim: Well-differentiated thyroid cancer (TC) comprises the most common endocrine malignancy, featuring very good prognosis and 5-year survival rate of nearly 100% after total thyroidectomy. However, the prevalence of incidental thyroid microcarcinoma (mITC) is continuously rising during the last decade. One obvious reason is the high prevalence of total thyroidectomy (TT) as the preferred operation for otherwise benign nodular or diffuse thyroid diseases. The current retrospec...

Aim: Thyroid cancer (TC) is the most common endocrine malignancy, presenting a rising incidence during the last decade, due to continuously rising prevalence of incidental thyroid microcarcinomas (mITCs; ≤1 cm) in benign thyroid diseases treated with total thyroidectomy (TT). Solitary thyroid nodule (STN) is a thyroid condition, which remains under debate regarding the extent of thyroidectomy needed (total or near-total thyroidectomy vs unilateral lobectomy). Objective o...

Objectives: • PCOS is defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders.• Women are exposed to increased risk for cardiovascular disease, hypertension, type 2 diabetes mellitus and other metabolic complications• Cardiovascular disease (CVD) is one of the most common cause of mortality wor...

IntroductionA strong association between autoimmune atrophic gastritis and other autoimmune disorders has been well documented. The prevalence of gastric mucosa alterations in patients with thyroid autoimmunity is not well known. The aim of our study was to assess the prevalence of intestinal metaplasia in patients with Graves’ disease (GD) and positive anti-parietal cell antibodies (APCA).Methods<p class=...

Primary hyperaldosteronism may be due to an adrenal adenoma and is an increasingly recognized cause of secondary arterial hypertension. The disease causes hypokalemia and is usually treated surgically by excision of the adrenal adenoma. However, it appears that it may present with a clinical profile without arterial hypertension. The aim was to describe three cases of primary hyperaldosteronism who presented with hypokalemia and an adrenal adenoma with normal blood pressure. A...

IntroductionThe routine assessment of postmenopausal women involves screening for cardiometabolic risk factors and bone health. Evaluation of the liver function is not commonly performed, even though this could be easily performed with the use of indirect markers, such as the Fibrosis 4 score. Recent evidence supports an association between liver cirrhosis and bone turnover, affecting both the trabecular and the cortical bone. Therefore, we aimed to expl...

IntroductionIn this study we present data on the long-term outcomes of treatment of patients with moderate and severe GO.Methods98 patients with GO attending our clinic for the last 13 years and received treatment for moderate to severe GO were evaluated for their long-term response to treatment. Initial decision for treatment was based on activity and severity of the disease, assessed by CAS-score and NOSPEC...